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HIV Antibody Screening and Confirmation Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the human immunodeficiency virus (HIV), which your body makes in response to infection. It helps determine if you’ve been exposed to HIV.

Quick summary

["HIV antibodies may appear within weeks to months after exposure, helping identify potential infection early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
21339-7
Short code
HIV2 p55 Ab Ser Ql IB
Synonyms
HIV2 p55 Ab Ser Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for HIV antibodies in your blood or plasma. These antibodies are proteins your immune system produces when it encounters HIV. The presence of these antibodies suggests past or current infection, though results can vary based on when testing occurs after exposure.

How the Test Works

This test uses an immunoassay method to detect HIV antibodies. A small blood sample is taken, and the lab analyzes it to identify specific markers linked to HIV infection. Some tests may also include a screening phase followed by confirmation to ensure accuracy.

Why It’s Done

Doctors may order this test if you have risk factors for HIV (e.g., unprotected sex, shared needles, or exposure to infected blood), symptoms of infection, or if you’re part of a group at higher risk. It’s also used as part of routine testing in certain settings (e.g., prenatal care).

What to Expect Before the Test

No special preparation is needed, but inform your healthcare provider about any medications you’re taking or recent illnesses. Avoid alcohol before the blood draw if possible, as it may affect blood flow.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HIV Antibody Test

Frequently asked questions

A healthcare professional will insert a small needle into your arm to draw a blood sample. You may feel a slight pinch, but the procedure usually takes just a few minutes. You can sit or lie down comfortably during the draw.
What the Results Mean
A positive result means your test detected HIV antibodies, indicating a high likelihood of current or past HIV infection. A negative result means no antibodies were found, but this doesn’t guarantee you’re not infected—results can take time to develop after exposure. Follow-up testing may be recommended if you suspect exposure.
Early detection of HIV is critical. Positive results prompt immediate medical evaluation, treatment planning, and access to support services. Untreated HIV can weaken your immune system over time, but with proper care, many people live long, healthy lives. This test helps monitor infection status and guide preventive or therapeutic decisions.
How Long Does It Take to Get Results?
No fasting is required for this blood test. However, inform your provider about any medications or supplements you’re taking, as they may affect test results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy