HIV Integrase Resistance Genotyping (Genotypic Resistance Testing for HIV Integrase Mutations)
This test checks for specific mutations in the HIV integrase gene, which can indicate resistance to certain antiretroviral medications. It helps doctors tailor treatment plans to ensure the best response to therapy.
["Identifying drug-resistant HIV mutations to guide personalized treatment options."]
Key facts at a glance
- LOINC
- 100986-9
- Short code
- HIV integrase failed codons Islt Genotyp
- Synonyms
- HIV integrase failed codons Islt Genotyp
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- genotyping
- CPT
- 86701
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters for Your Treatment Plan
If your HIV treatment isn’t working as expected or if you’ve been on multiple medications, this test can help determine whether certain HIV strains have developed resistance to specific drugs. Resistance mutations may appear after prolonged or incorrect use of integrase strand transfer inhibitors (INSTIs), a common class of HIV medications.
How the Test Works
A small blood sample is collected to analyze the genetic sequence of the HIV integrase gene. Advanced laboratory techniques identify any mutations that may reduce the effectiveness of certain antiretroviral drugs. This process helps doctors adjust your treatment to improve viral suppression.
When You Might Need This Test
You may need this test if you’re experiencing treatment failure (viral load remains high despite therapy), if you’ve switched medications frequently, or if you’ve been diagnosed with drug-resistant HIV. It’s also used in pre-treatment counseling for patients considering specific INSTI-based regimens.
What to Expect Before the Test
No special preparation is needed. A healthcare provider will draw blood, typically from your arm, and send it to a lab for analysis. The results may take several days to weeks, depending on lab processing times.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
HIV Integrase Resistance Genotype
Frequently asked questions
How can I know if my HIV treatment is working?
Will this test affect my current medications?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy