Human Leukocyte Antigen (HLA) Class I Grouping (Serum/Plasma)
This test identifies specific human leukocyte antigen (HLA) Class I molecules found on the surface of most cells in your body. These antigens play a key role in immune response and compatibility for organ transplants.
["Helps assess immune function and compatibility for potential organ transplants."]
Key facts at a glance
- LOINC
- 94446-2
- Short code
- HLA-A + B + C (class I) IgG Pnl SerPl FC
- Synonyms
- HLA-A + B + C (class I) IgG Pnl SerPl FC
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- flow-cytometry
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is HLA Class I Testing Used For?
HLA Class I testing is primarily used in the context of organ transplantation to determine genetic compatibility between donors and recipients. It helps reduce the risk of rejection by identifying shared or mismatched antigens that could trigger an immune response.
How Is This Test Performed?
This test involves drawing blood from a vein in your arm. The serum or plasma sample is then analyzed using immunoassay techniques to detect specific HLA Class I antigens. Results are reported as positive or negative for each tested allele.
Why Might You Need This Test?
You may need HLA Class I testing if you are a potential organ donor or recipient, particularly for procedures like kidney, liver, or bone marrow transplants. It may also be part of a broader evaluation for autoimmune conditions or immune-related research studies.
What Are Common Clinical Uses?
Common clinical uses include pre-transplant evaluation to match donors and recipients, diagnosing certain autoimmune diseases, and genetic studies involving immune function.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance of HLA Class I testing includes determining transplant compatibility, assessing risk for graft rejection, and guiding treatment decisions in autoimmune disorders where immune response is dysregulated.
Short name
HLA Class I Typing
Frequently asked questions
Why do doctors order HLA Class I testing for transplant candidates?
How long does it take to get results from this test?
Is there any preparation needed before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy