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Human Leukocyte Antigen (HLA) Typing – Class I (A, B, C) Genotyping

Published: August 9, 2026Updated: August 16, 2026

This test identifies specific genetic markers (HLA-A, HLA-B, HLA-C) found on white blood cells, which play a key role in immune response and organ compatibility.

Quick summary

["Helps assess risk for autoimmune diseases, organ transplant compatibility, and certain blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72328-8
Short code
HLA-A+B+C IgG Ser Ql FC
Synonyms
HLA-A+B+C IgG Ser Ql FC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects the presence and variation of HLA-A, HLA-B, and HLA-C genes. These genes encode proteins on the surface of white blood cells that help the immune system recognize foreign substances. Variations in these genes can influence how the body responds to infections, autoimmune conditions, or foreign tissues (e.g., in transplants).

Why It’s Ordered

Doctors may order this test to evaluate risks for autoimmune diseases (e.g., rheumatoid arthritis, lupus), plan organ transplants, or diagnose conditions like blood disorders or certain cancers where HLA matching is important.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The sample is processed to isolate white blood cells, where the HLA genes are analyzed using advanced genetic testing methods.

What to Expect Before the Test

No special preparation is needed, but inform your healthcare provider if you are pregnant, have an infection, or are on certain medications that might affect immune function.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HLA Class I Genotyping

Frequently asked questions

How might my results affect my health?
Results can help identify genetic predispositions to autoimmune diseases or guide decisions for organ transplants. For example, matching HLA types between donors and recipients improves transplant success. Abnormal results may require further evaluation by a specialist.
What do my results mean?
Results show which specific HLA alleles (versions) you carry. These can indicate higher or lower risks for certain conditions, but interpretation depends on clinical context and additional testing. Always discuss results with your healthcare provider.
Can this test be used for anything else?
Yes, this test is primarily used for immune-related conditions and transplant compatibility. It is not typically used for general screening or routine health monitoring.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy