Human Leukocyte Antigen (HLA) Antibody Screening and Confirmation (Serum/Plasma)
This test helps detect antibodies in your blood that may react against specific human leukocyte antigens (HLA), which are proteins found on the surface of cells. These antibodies can be linked to conditions like organ transplant rejection or autoimmune responses.
["This test helps identify potential immune reactions that may affect organ transplantation or autoimmune conditions."]
Key facts at a glance
- LOINC
- 78013-0
- Short code
- HLA-A + B + DRB + DQB1 Pnl Bld/T Low res
- Synonyms
- HLA-A + B + DRB + DQB1 Pnl Bld/T Low res
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- low-resolution
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may recommend this test if you’re preparing for an organ transplant, experiencing unexplained organ rejection, or have symptoms that suggest an autoimmune condition. It helps determine if your immune system is producing antibodies that could interfere with treatment or recovery.
What Does the Test Involve?
A blood sample is drawn from a vein, typically in your arm. The serum or plasma is then tested for the presence of specific HLA antibodies using sensitive laboratory methods, such as immunoassay techniques.
What to Expect Before the Test
There are no special preparations needed for this test. You can eat, drink, or take your usual medications as usual. If you’re scheduled for an organ transplant, your provider may provide specific instructions to ensure accurate results.
What Are the Possible Results?
The test results will indicate whether antibodies are present against certain HLA types. Positive results mean your immune system has detected these antibodies, which may influence transplant compatibility or autoimmune management.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test plays a critical role in transplant medicine by identifying potential immune responses that could lead to rejection. In autoimmune conditions, it may help guide treatment decisions by confirming the presence of antibodies linked to disease activity. Results are used to tailor therapies and monitor immune activity.
Short name
HLA Antibody Panel
Frequently asked questions
What does a positive result mean?
How often will I need this test?
Can I eat or drink anything before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy