Human Leukocyte Antigen (HLA) Antibody Screening, Serum
This test checks for antibodies against specific human leukocyte antigens (HLA) in your blood, which can help identify potential risks of organ rejection or certain autoimmune conditions.
["This screening helps guide decisions about organ transplants or conditions linked to immune responses."]
Key facts at a glance
- LOINC
- 110826-5
- Short code
- HLA Ab Msmt Ser
- Synonyms
- HLA Ab Msmt Ser
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is an HLA Antibody Screen Used For?
HLA antibodies are proteins found on the surface of cells that help the immune system recognize foreign substances. In this test, we look for antibodies that may react against HLA proteins from a potential organ donor (e.g., kidney, heart, or other tissues). This screening is critical before organ transplants to prevent rejection or in diagnosing conditions like lupus, rheumatoid arthritis, or other autoimmune diseases where antibodies may play a role.
How Is This Test Performed?
A small blood sample is drawn from your arm. The serum (liquid part of blood without clots) is then tested using immunoassay methods to detect the presence of specific HLA antibodies. Results are qualitative, meaning they indicate whether antibodies are present or not.
Preparation for the Test
No special preparation is needed for this test. You may eat and drink as usual before your appointment. If you are scheduled for an organ transplant, your healthcare team will provide specific instructions.
What Are the Possible Results?
A positive result means antibodies against certain HLA proteins are detected. This may increase the risk of organ rejection if a transplant is planned or could suggest an autoimmune condition. A negative result means no antibodies were found in this test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
HLA antibody screening is vital in organ transplantation to match donor and recipient HLA profiles to minimize rejection. Positive results may also be linked to autoimmune diseases, where the immune system mistakenly attacks healthy tissues. Your doctor will discuss results in the context of your medical history and treatment plan.
Short name
HLA Antibody Screen
Frequently asked questions
Why might I need this test?
What does a positive result mean?
How often will I need this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy