Human Leukocyte Antigen (HLA) Antibody Screening (Serum)
This test checks for antibodies in your blood that may react against certain proteins found on white blood cells, often used to assess compatibility for organ transplants or pregnancy-related conditions.
["Helps determine if you have antibodies that could affect organ transplant success or pregnancy outcomes."]
Key facts at a glance
- LOINC
- 44534-6
- Short code
- HLA Ab Ser Ql
- Synonyms
- HLA Ab Ser Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you’re considering an organ transplant, have a history of pregnancy complications (like preeclampsia or recurrent miscarriages), or are being evaluated for conditions like lupus or other autoimmune diseases. It helps ensure compatibility between donor and recipient or identify potential risks.
What to Expect During the Test
A small blood sample is drawn from a vein in your arm. The blood is then tested for specific antibodies that could react against HLA proteins. Results are qualitative (positive or negative) rather than measuring exact amounts.
Sample Collection and Preparation
The test uses serum (liquid part of blood after clotting) and is typically processed within 24 hours of collection. No special preparation is needed, but fasting may not be required unless instructed by your provider.
What the Results Mean
Positive results indicate the presence of certain HLA antibodies, which may influence decisions about organ transplants, pregnancy management, or further diagnostic testing. Negative results mean no detectable antibodies of the tested types.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive HLA antibodies can increase risks in organ transplantation by triggering immune rejection or in pregnancy by affecting fetal development. These antibodies may also be linked to autoimmune conditions, where the immune system mistakenly attacks healthy cells. Your provider will discuss results in the context of your medical history and treatment plan.
Short name
HLA Antibody Screen
Frequently asked questions
What does a positive result mean for my health?
How often will I need this test?
Can I prepare for this test differently?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy