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Human Leukocyte Antigen (HLA) Antibody Screening (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies in your blood that may react against certain proteins found on white blood cells, often used to assess compatibility for organ transplants or pregnancy-related conditions.

Quick summary

["This test helps determine if you have antibodies that could affect organ transplant success or pregnancy outcomes."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
78014-8
Short code
HLA-A Low res
Synonyms
HLA-A Low res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
low-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you’re a potential organ donor, considering pregnancy complications (such as preeclampsia or recurrent miscarriage), or preparing for a transplant. It helps identify potential immune reactions that could impact treatment outcomes.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. The test is quick and typically done in a lab setting.

What the Results Mean

Positive results indicate the presence of certain HLA antibodies, which may influence decisions about organ donation, pregnancy management, or transplant compatibility. Negative results suggest no significant antibodies are detected.

Common Conditions Monitored

This test is often used in transplant medicine (e.g., kidney, liver) to assess donor-recipient compatibility and in obstetrics to evaluate risks in high-risk pregnancies.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HLA Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies that may react against specific proteins on donor cells or fetal cells, potentially affecting transplant success or pregnancy health. Your doctor will discuss next steps based on your specific situation.
How often is this test repeated?
Frequency depends on your medical reason for testing. For transplants, it may be done pre-surgery and periodically afterward. For pregnancy-related cases, it could be repeated during monitoring phases.
Can lifestyle changes affect HLA antibody levels?
HLA antibody levels are primarily influenced by immune system factors rather than lifestyle. However, managing chronic conditions (like diabetes or autoimmune diseases) may indirectly impact overall health and test relevance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy