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Serum or plasma donor-specific antibody screen (blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies in your blood that might react with antibodies found in donated blood products, helping ensure compatibility for transfusions.

Quick summary

["Helps prevent transfusion reactions by identifying potential antibody mismatches."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96632-5
Short code
HLA-Bw Donr
Synonyms
HLA-Bw Donr
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re a blood donor or if you’re receiving blood products (like plasma or platelets) to prevent adverse reactions. It’s also used in blood banks to screen donated blood for compatibility with recipients.

How the Test Works

A small sample of your blood is tested to detect antibodies that could react with donor blood components. The test uses a method called immunoassay to identify these antibodies by mixing your blood with donor blood cells.

What to Expect Before the Test

No special preparation is needed. You’ll have a simple blood draw, similar to other routine blood tests. If you’re a donor, you may be asked to provide a sample for screening as part of your donation process.

What the Results Mean

If antibodies are found, they may indicate a risk of transfusion reactions if certain donor blood products are used. Your healthcare provider will discuss the results with you and may recommend further testing or adjustments to your treatment plan.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Donor Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies that could potentially react with donor blood components, increasing the risk of transfusion-related complications. This is why it’s critical for blood banks to screen donors carefully.
How often should I get this test?
The frequency depends on your medical history, treatment plan, or donation status. If you’re a blood donor, you’ll be screened as part of your routine donation process. Your healthcare provider will determine how often you need retesting if you’re receiving blood products.
Can I donate blood if this test is positive?
Not necessarily. If antibodies are detected, you may need further evaluation to determine if you’re eligible to donate blood or if you require special precautions during transfusions. Always follow your healthcare provider’s guidance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy