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High-Resolution Donor-Specific Antibody Screening by Immunofluorescence

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific antibodies in donated blood that could react with certain blood types, helping ensure compatibility for transfusions.

Quick summary

["Helps prevent transfusion reactions by identifying potential blood type mismatches in donated blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96621-8
Short code
HLA-C Donr High Res
Synonyms
HLA-C Donr High Res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
high-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Blood donors may undergo this test if they have a history of blood transfusions, certain blood disorders, or if they’re being screened for compatibility with specific blood types. It’s also used to monitor antibody levels in patients receiving blood transfusions or stem cell therapy.

What to Expect Before the Test

You’ll donate a small blood sample, similar to a regular blood draw. No special preparation is needed, but inform your donor center about any medications or recent illnesses.

How the Test Works

The donated blood sample is tested using immunofluorescence to detect antibodies that may react with red blood cells from certain blood types. High-resolution testing helps identify rare or specific antibodies that standard tests might miss.

What the Results Mean

Positive results indicate the presence of antibodies that could cause reactions in recipients. Negative results mean no significant antibodies were detected in this sample. Follow-up testing may be needed if antibodies are found.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is critical for preventing transfusion-related complications, such as hemolytic reactions, by ensuring donated blood is compatible with the recipient’s blood type. It’s especially important for patients with rare blood types or those who’ve had previous transfusion reactions.

Short name

High-Res Antibody Screen (Donor)

Frequently asked questions

What does a positive result mean for my donated blood?
A positive result means your donated blood may contain antibodies that could react with certain blood types in recipients. This blood may not be suitable for all patients, and it may need further testing or be restricted to specific blood type recipients.
Will I be asked to donate again if this test comes back positive?
Yes, you may be asked to donate again after further evaluation. Your donor center will guide you on next steps, which may include additional testing or deferral from donation until antibody levels change.
Can I still donate if I have a history of blood transfusions?
Yes, but you may need to provide additional medical information and possibly undergo further testing. Your eligibility depends on your specific circumstances and the donor center’s policies.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy