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High-Sensitivity C-Reactive Protein (hs-CRP) in Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by the liver in response to inflammation, helping assess low-level inflammation in your body.

Quick summary

["hs-CRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96634-1
Short code
HLA-C Donr Low res
Synonyms
HLA-C Donr Low res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
low-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order hs-CRP to evaluate risk factors for heart disease, monitor chronic conditions like arthritis or lupus, or check for signs of inflammation after surgery or injury. It’s often used alongside other tests to guide treatment decisions.

What Does the Result Mean?

Results are not given in a single range because they vary by health status and medical context. Higher levels may indicate inflammation, while lower levels suggest reduced inflammation. Your doctor will interpret the result in relation to your overall health and symptoms.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is separated into serum or plasma for testing. The hs-CRP is measured using a sensitive immunoassay method to detect even small amounts of the protein.

What Are Common Causes of Abnormal Results?

Elevated hs-CRP can be caused by infections, autoimmune diseases, obesity, smoking, or certain medications. Lower levels may occur with reduced inflammation or certain medications. Other factors like age, sex, and recent illness can also affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

hs-CRP

Frequently asked questions

What does hs-CRP measure?
hs-CRP measures the concentration of a protein called C-reactive protein, which rises in response to inflammation in your body. It’s often used as a marker to assess overall inflammatory activity, especially in conditions like cardiovascular disease or chronic inflammation.
Can hs-CRP replace other tests like CRP?
No, hs-CRP is a more sensitive version of the traditional CRP test. While both measure inflammation, hs-CRP can detect lower levels of inflammation that might not be detected by standard CRP tests. Your doctor may use hs-CRP alongside other tests for a complete picture.
How often should I get this test?
The frequency depends on your health condition and doctor’s recommendations. Some people may need hs-CRP testing every few months or annually, while others may only need it once or twice a year, depending on their treatment plan and symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy