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High-Resolution Alpha-1 Antitrypsin (A1AT) Profile by Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the different forms of alpha-1 antitrypsin (A1AT) proteins in your blood using high-resolution electrophoresis. It helps identify variations that may affect how well your body protects lung tissue or liver cells.

Quick summary

["This test helps diagnose or monitor conditions linked to abnormal A1AT levels or variants."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77636-9
Short code
HLA-C High Res
Synonyms
HLA-C High Res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
high-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of lung diseases (like chronic obstructive pulmonary disease or emphysema), liver problems, or if you have a family history of A1AT deficiency. It can also be used to check for rare A1AT variants that might not be detected by standard tests.

What to Expect During the Test

A simple blood draw is used to collect a small amount of serum or plasma. The sample is then analyzed in a lab using electrophoresis to separate and identify different A1AT protein types.

Common Conditions Monitored

This test helps identify or confirm conditions such as alpha-1 antitrypsin deficiency, which can lead to lung diseases or liver damage. It may also be used to assess how certain treatments might affect A1AT levels.

What the Results Mean

Results show the distribution of different A1AT protein types. Abnormal patterns may indicate a genetic variant or deficiency. Your doctor will interpret the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency and Beyond

Short name

A1AT High-Resolution Profile

Frequently asked questions

What are the normal ranges for this test?
There are no standard numeric reference ranges for high-resolution A1AT profiles because the test focuses on identifying patterns (e.g., Z-zeta, S-sigma, or normal variants) rather than absolute concentrations. Your results will be compared to known patterns in the lab and discussed with your doctor.
How long does it take to get my results?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will contact you once they are ready.
Can I fast before this test?
No fasting is required for this blood test. However, always follow your doctor’s instructions for any specific preparation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy