Serum or Plasma Protein Electrophoresis (Qualitative) with Bromocresol Green Staining

What This Test Measures

Electrophoresis separates blood proteins based on their size and electrical charge. Bromocresol Green dye binds to specific proteins, allowing for visual differentiation of albumin, alpha-globulins, beta-globulins, and gamma-globulins. This qualitative method helps detect abnormal protein bands or shifts that may indicate underlying health issues.

Why It’s Done

Your healthcare provider may order this test to investigate symptoms like unexplained weight loss, fatigue, swelling, or abnormal lab results. It’s also used to monitor conditions such as multiple myeloma, liver disease, or certain autoimmune disorders where protein patterns can change over time.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The sample is then processed to separate serum or plasma, which is sent to the lab for electrophoresis. The results are visually interpreted to assess protein distribution.

Common Conditions Evaluated

This test helps identify conditions where protein patterns deviate from normal, such as: - Multiple myeloma (cancer of plasma cells) - Liver or kidney disease (affecting protein synthesis or clearance) - Certain autoimmune diseases (e.g., rheumatoid arthritis) - Inflammatory conditions (e.g., infections or chronic illnesses).