Genetic test for detection of unresolved donor alleles in kidney transplant recipients (e.g., HLA mismatch screening)

Why This Test Matters

Kidney transplant recipients often receive a donor kidney with different HLA (human leukocyte antigen) genes than their own. If your immune system doesn’t fully accept these new genes, it may reject the kidney over time. This test helps identify if any donor-specific HLA alleles remain detectable, which could signal an ongoing risk of rejection or graft failure.

What It Measures

The test detects the presence of donor HLA alleles in your blood or other body fluids. It uses advanced genetic sequencing to compare your immune system’s genes against those of the donor kidney.

When It’s Ordered

This test is typically performed during routine follow-up visits for kidney transplant patients, especially if you’ve had signs of rejection (e.g., increased blood pressure, swelling, or changes in kidney function). It may also be done before certain procedures or if your doctor suspects incompatibility issues.

What to Expect

You’ll provide a blood sample, which is then analyzed in a lab using genetic testing methods. Results are usually available within 1–2 weeks. Your doctor will discuss the findings with you during your next appointment.