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Genetic testing for high-resolution analysis of HLA-DPA1 alleles (unresolved alleles)

Published: August 9, 2026Updated: August 16, 2026

This test evaluates specific genetic variations in the HLA-DPA1 gene, which plays a role in immune response. High-resolution analysis helps identify precise allele differences that may influence susceptibility to certain diseases or reactions to treatments.

Quick summary

This test helps doctors understand genetic variations that could affect immune function or treatment responses.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96645-7
Short code
HLA-DPA1 Unreslvd Alleles High Res
Synonyms
HLA-DPA1 Unreslvd Alleles High Res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
high-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of autoimmune diseases, certain cancers, or if you’re considering organ transplantation. It may also be used to assess compatibility for blood or stem cell donations or to guide personalized treatment plans for immune-related conditions.

What to Expect Before the Test

No special preparation is needed for this genetic test. A small blood sample is typically collected from a vein in your arm, similar to a regular blood draw. Results are usually available within days to weeks, depending on laboratory processing times.

How the Results Are Used

The results identify specific HLA-DPA1 alleles present in your DNA. These findings can help determine the likelihood of developing certain immune-related conditions, assess transplant compatibility, or tailor therapies to match your genetic profile.

What the Results Mean

High-resolution allele identification helps narrow down genetic variations that may influence immune responses. For example, certain allele combinations are linked to higher risks of autoimmune diseases or lower risks of rejection in transplant patients. Your provider will interpret these results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HLA-DPA1 Allele High-Resolution Test

Frequently asked questions

How often does this test cause false positives or false negatives?
This genetic test is highly specific and designed to detect precise allele variations. However, like all genetic tests, results should be interpreted by a healthcare provider who considers your full medical context. False results are rare but can occur if sample errors or technical issues occur during testing.
What if my results show unusual or unknown alleles?
If your results reveal alleles not commonly found in the general population, your healthcare provider may consult additional genetic databases or specialists to understand their potential implications. Some alleles may require further evaluation or monitoring depending on their association with known conditions.
Can this test be used for prenatal or carrier screening?
This test is primarily used for diagnostic or compatibility purposes in adults, not prenatal screening. If you’re concerned about genetic risks in pregnancy, consult a genetic counselor for appropriate screening options tailored to your needs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy