High-Resolution Serum Protein Electrophoresis (HrspE)

What This Test Measures

High-resolution serum protein electrophoresis separates proteins into distinct bands, revealing their relative amounts. This includes globulins (antibodies, acute-phase proteins), albumin, and other fractions. The results help pinpoint abnormalities in protein distribution that may signal underlying health issues.

Why It’s Done

Your healthcare provider may order this test to diagnose or monitor conditions such as multiple myeloma, lymphoma, autoimmune diseases, or chronic liver disease. It can also assess protein loss in conditions like nephrotic syndrome or detect subtle changes in protein composition due to aging or metabolic disorders.

Sample Collection and Preparation

A blood sample is drawn from a vein, typically in your arm. The blood is processed to separate serum (the liquid part after clotting) for analysis. High-resolution electrophoresis requires specialized equipment to separate proteins into finer fractions than standard tests.

Common Conditions Evaluated

This test helps identify abnormal protein patterns linked to diseases affecting protein synthesis, storage, or breakdown. For example, it may show elevated or low levels of specific globulins, which can indicate immune system dysfunction or organ damage.