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Genetic test for high-resolution analysis of HLA-DPB1 alleles (serum/plasma specimen)

Published: August 9, 2026Updated: August 16, 2026

This test identifies specific variations (alleles) in the HLA-DPB1 gene, which play a role in immune response and may influence susceptibility to certain diseases or reactions to medications.

Quick summary

Understanding your HLA-DPB1 alleles can help tailor treatments for autoimmune conditions, organ transplants, or allergic responses.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96651-5
Short code
HLA-DPB1 Unreslvd Alleles High Res
Synonyms
HLA-DPB1 Unreslvd Alleles High Res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
high-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects precise genetic differences (alleles) in the HLA-DPB1 region, a part of the major histocompatibility complex (MHC) involved in immune function. These alleles are inherited and can affect how your body responds to infections, tissues, or medications.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you’re at risk for autoimmune diseases, need a tissue match for organ transplantation, or are being evaluated for conditions where HLA-related genetic factors play a role.

Common Uses in Healthcare

Applications include pre-transplant compatibility assessments, diagnosing or monitoring autoimmune disorders (e.g., rheumatoid arthritis), or evaluating responses to certain drugs (e.g., HLA-B*5801 and drug-induced hypersensitivity).

What to Expect Before the Test

No special preparation is typically needed. A blood sample is drawn from a vein, similar to other blood tests. If you’re taking blood thinners, inform your provider beforehand.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HLA-DPB1 High-Resolution Genotyping

Frequently asked questions

High-resolution HLA-DPB1 testing helps identify rare or specific genetic variants that may influence immune responses, disease risk, or treatment outcomes. This precision can guide personalized medical decisions.
This test is not a routine screening and is usually ordered based on clinical suspicion or specific patient needs (e.g., transplant candidates, autoimmune disease management).
How long will results take?
Results can take several days to a few weeks, depending on laboratory processing and follow-up steps. Your provider will contact you once results are ready.
What if my results are abnormal?
Abnormal results may indicate a genetic variation linked to immune function or disease risk. Your provider will discuss findings in detail and recommend next steps, such as further testing or treatment adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy