Genetic test for detecting specific alleles associated with hereditary angioedema (C1 esterase inhibitor deficiency)
This test checks for genetic variants linked to hereditary angioedema, a rare but serious condition causing sudden, painful swelling in parts of the body.
["This test helps diagnose hereditary angioedema by examining DNA for known risk alleles."]
Key facts at a glance
- LOINC
- 96655-6
- Short code
- HLA-DQA1 Unreslvd Alleles Donr High Res
- Synonyms
- HLA-DQA1 Unreslvd Alleles Donr High Res
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- high-resolution
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you or a family member has symptoms like unexplained swelling (especially in the face, throat, or abdomen), frequent swelling episodes, or a history of hereditary angioedema in your family. It’s also used for genetic counseling or before certain surgeries.
What to Expect Before the Test
No special preparation is needed. A simple blood sample will be taken from your arm. If testing is done on a family member, they may need to provide a blood sample as well.
What the Results Mean
Results will indicate whether you carry the known alleles linked to hereditary angioedema. If you do, it confirms a genetic predisposition, but symptoms may still vary. Treatment options can be discussed with your doctor.
Common Symptoms of Hereditary Angioedema
Symptoms may include sudden, severe swelling in the face, throat, limbs, or abdomen, which can occur without warning. Unlike allergic reactions, these attacks often happen without itching or hives.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is critical for confirming a hereditary condition that can’t be diagnosed by symptoms alone. Early identification allows for proactive management, including preventive medications or lifestyle adjustments to reduce risk during flare-ups. It also supports genetic counseling for family members who may inherit the condition.
Short name
Hereditary Angioedema (C1-INH) Genetic Test
Frequently asked questions
What does a positive test result mean?
How often should I get this test?
Can lifestyle changes prevent hereditary angioedema attacks?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy