High-Resolution Serum Protein Electrophoresis (High-Resolution Serum Protein Electrophoresis)

What Does This Test Measure?

High-resolution serum protein electrophoresis separates proteins in your blood into distinct fractions (e.g., albumin, alpha-globulins, beta-globulins, and gamma-globulins) using gel electrophoresis. This helps detect abnormalities in protein levels that may signal conditions like multiple myeloma, liver disease, or other protein-related disorders.

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like unexplained weight loss, fatigue, swollen lymph nodes, or signs of liver/kidney disease. It’s also used to monitor conditions like multiple myeloma or other protein disorders.

Sample Preparation and Testing Process

A blood sample is drawn, and serum is separated for testing. The serum is then applied to a gel and subjected to an electric current, causing proteins to migrate based on size and charge. The resulting bands are analyzed to determine protein distribution.

Common Conditions Monitored or Diagnosed

This test helps diagnose or monitor conditions such as multiple myeloma (a cancer of plasma cells), Waldenström macroglobulinemia, liver disease, nephrotic syndrome, and certain autoimmune disorders.