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High-Sensitivity C-Reactive Protein (hsCRP) – Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when inflammation is present, often used to assess low-level inflammation or risk of future health issues.

Quick summary

["Helps track subtle inflammation or cardiovascular risk over time."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
78017-1
Short code
HLA-DQB1 Low res
Synonyms
HLA-DQB1 Low res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
low-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why It’s Done

Your doctor may order this test to monitor chronic conditions like arthritis, heart disease, or other inflammatory disorders. It’s also used in research or screening for early signs of inflammation that standard tests might miss.

What to Expect

A small blood sample is drawn from your arm. The test is quick and typically done in a lab. Results are usually ready within a few days.

How It Works

Your blood is analyzed to detect levels of hsCRP, a marker for inflammation. The test uses a sensitive method to measure even small amounts of this protein.

Common Uses

Helps evaluate risk for heart disease, track inflammation in autoimmune conditions, or guide treatment decisions for conditions like rheumatoid arthritis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hsCRP

Frequently asked questions

What does a high hsCRP level mean?
A high hsCRP level suggests inflammation is present in your body, which could be linked to conditions like heart disease, infections, or autoimmune disorders. Your doctor will consider this along with other test results and your medical history to guide further action.
How often should I get this test?
Your doctor will determine how often you need this test based on your health needs, symptoms, and treatment plan. It’s often done periodically for monitoring, especially if you have chronic conditions like heart disease or arthritis.
Can lifestyle changes affect hsCRP levels?
Yes, diet, exercise, and managing stress can influence inflammation levels. Small changes like eating a heart-healthy diet, staying active, or quitting smoking may help lower hsCRP over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy