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HLA-DQB1 unresolved alleles

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific genetic variations linked to Alpha-1 Antitrypsin (A1AT) deficiency, a condition that can affect lung and liver health by reducing the body’s ability to produce a protective protein.

Quick summary

This test helps identify if you carry genetic mutations that may increase your risk for lung diseases or liver problems over time.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96661-4
Short code
HLA-DQB1 Unreslvd Alleles High Res
Synonyms
HLA-DQB1 Unreslvd Alleles High Res
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
high-resolution
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of Alpha-1 Antitrypsin deficiency, symptoms like chronic cough, wheezing, or liver-related issues, or if you’re at higher risk due to ethnicity (e.g., Northern or Western European ancestry).

What the Test Measures

The test analyzes DNA from a blood sample to detect specific alleles (versions of the gene) associated with reduced or absent A1AT production. High-resolution genotyping provides detailed information about these genetic variations.

Sample Collection and Preparation

A small blood sample is drawn from your arm. The blood is processed to isolate DNA, which is then tested in a laboratory using advanced genetic techniques.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid certain medications (like blood thinners) if directed by your provider. Bring a list of all current medications to your appointment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Having certain alleles of the A1AT gene can increase your risk for developing chronic obstructive pulmonary disease (COPD) or liver diseases like cirrhosis. Early detection allows for monitoring, lifestyle adjustments, and potential interventions to manage symptoms and complications.

Short name

Alpha-1 Antitrypsin (A1AT) Gene Allele Screening

Frequently asked questions

How long does it take to get results?
Results are typically available within 1 to 2 weeks, depending on the laboratory and your healthcare provider’s workflow. Your provider will discuss the findings with you during a follow-up visit.
What do my results mean?
Results will indicate whether you carry the specific alleles linked to A1AT deficiency. If you do, your provider may recommend further testing, lifestyle counseling, or referrals to specialists for ongoing management.
Can I have this test if I’m pregnant?
Yes, this genetic test can be performed during pregnancy if medically necessary. However, discuss any concerns with your healthcare provider, as some genetic tests may not be recommended for all pregnancies depending on individual risk factors.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy