: HLA-DRB1 Low-Resolution Typing
: This test identifies the broad HLA-DRB1 gene types a person carries using low-resolution typing. It is used in tissue and transplant matching and in some disease or drug-sensitivity assessments.
[": Low-resolution HLA-DRB1 typing groups your DRB1 variants into broad type categories rather than identifying exact genetic variants."]
Key facts at a glance
- LOINC
- 96664-8
- Short code
- HLA-DRB1 Low res
- Synonyms
- HLA-DRB1 Low res
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- low-resolution
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
: What This Test Measures
: HLA-DRB1 is a gene in the human leukocyte antigen (HLA) system, which helps the immune system recognize self from non-self. Low-resolution typing reports the major DRB1 type groups (for example, broad DR1, DR4, or DR15 families) rather than the precise allele.
: Why It Is Ordered
: It may be ordered as part of HLA typing for transplant or donor evaluation, to support compatibility assessment, or in certain clinical evaluations where an HLA type association is relevant. Your care team determines whether low-resolution typing is appropriate for your situation.
: How the Sample Is Collected
: The test is typically performed on a blood sample, and sometimes on other specimens such as saliva or a buccal swab, depending on the laboratory and purpose. No special preparation is usually required unless your provider instructs otherwise.
: How to Interpret Results
: Results list the broad HLA-DRB1 types detected. These types are shared by many people and are not by themselves a diagnosis of any disease. Interpretation depends on why the test was ordered and is best reviewed with your provider or a genetics/transplant specialist.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
: HLA-DRB1 low-resolution typing provides broad immunogenetic information used mainly for compatibility and association assessments. Because low-resolution results do not define exact alleles and HLA types vary across populations, findings must be interpreted in the full clinical context by the ordering provider.
Short name
: HLA-DRB1 (low resolution)
Frequently asked questions
: Does this test diagnose a disease?
: What is the difference between low-resolution and high-resolution HLA typing?
: Will I need to repeat this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy