High-Resolution Antibody Profile for HLA-DRB3 (Unresolved High-Resolution)
This test measures antibodies against the HLA-DRB3 gene, which plays a role in immune response and organ compatibility. It helps identify potential immune reactions in transplant candidates or patients with autoimmune conditions.
["This test helps assess compatibility for organ transplants or autoimmune conditions by detecting specific antibodies."]
Key facts at a glance
- LOINC
- 96675-4
- Short code
- HLA-DRB345 Unreslvd High Res
- Synonyms
- HLA-DRB345 Unreslvd High Res
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- high-resolution
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you’re a candidate for organ transplantation (e.g., kidney, liver) or if you have symptoms like chronic inflammation, organ rejection risks, or autoimmune diseases. It helps ensure a safer transplant match or monitor immune activity.
What to Expect Before the Test
No special preparation is needed unless instructed by your doctor. Blood will be drawn from a vein in your arm. If you’re a transplant candidate, you may need to fast for 8–12 hours before testing.
What the Results Mean
Positive results indicate the presence of antibodies against HLA-DRB3, which may affect transplant compatibility or immune function. Results are interpreted by your healthcare provider in the context of your medical history.
Common Reasons for Testing
This test is often used in transplant medicine to screen donors and recipients for HLA mismatches that could trigger immune rejection. It may also be part of broader antibody panels for autoimmune diseases like lupus or rheumatoid arthritis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
High-resolution HLA antibody testing is critical for transplant medicine to minimize rejection risks by matching donor-recipient compatibility. In autoimmune conditions, detecting HLA-related antibodies helps guide treatment decisions to reduce flare-ups or organ damage. Results may influence transplant waitlisting, donor selection, or immunosuppressive therapy.
Short name
HLA-DRB3 Antibody Screening (High-Res)
Frequently asked questions
Will this test affect my transplant eligibility?
How long will I need to wait for results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy