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HLA-DR Cell Surface Antigen (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test identifies specific human leukocyte antigen (HLA) markers on white blood cells, often used to assess immune response or compatibility for organ transplants.

Quick summary

["HLA-DR typing helps match donors and recipients for medical procedures or evaluate immune function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107071-3
Short code
HLA-DR+ Cells NFr Bld FC
Synonyms
HLA-DR+ Cells NFr Bld FC
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

HLA-DR is a protein found on the surface of immune cells, including white blood cells. Different variations (alleles) of HLA-DR exist, and this test detects which ones are present in your sample. These markers play a key role in how your immune system recognizes foreign substances and responds to infections or transplants.

Why It’s Done

Doctors may order this test to: determine compatibility between potential organ donors and recipients, investigate autoimmune conditions, or evaluate immune responses in certain diseases.

Sample Collection

A blood sample is drawn from a vein in your arm. The blood is then processed to separate the cells from the liquid part (serum or plasma). This liquid is tested for specific HLA-DR markers.

Preparation

No special preparation is needed, but you may be asked to avoid certain medications or activities for a short time before testing, depending on your specific situation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

HLA-DR typing is critical in transplant medicine to reduce rejection risks. Abnormalities may also be linked to autoimmune diseases or immune deficiencies, though results alone don’t diagnose conditions.

Short name

HLA-DR typing (serum/plasma)

Frequently asked questions

How long will I need to wait for results?
Results can take several days to a couple of weeks, depending on the lab’s processing time and whether additional testing is needed.
What does a positive or negative result mean?
A positive result indicates the presence of specific HLA-DR markers in your sample. These markers don’t have a simple 'normal' or 'abnormal' interpretation alone; they’re used in combination with other factors (e.g., donor/recipient matching).
Can I influence my HLA-DR markers?
No, HLA-DR markers are inherited and cannot be changed through diet, lifestyle, or supplements. They are determined by your genetic makeup.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy