HLA-DR Cell Surface Antigen (Serum/Plasma) – Quantitative Immunoassay
This test measures the presence and level of antibodies against HLA-DR antigens, which are proteins found on the surface of immune cells. It helps assess immune compatibility for organ transplantation or diagnose autoimmune conditions.
["Helps determine if your immune system may reject a transplanted organ or identify autoimmune reactions."]
Key facts at a glance
- LOINC
- 107070-5
- Short code
- HLA-DR+ Cells NFr Spec FC
- Synonyms
- HLA-DR+ Cells NFr Spec FC
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- flow-cytometry
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you’re a potential organ donor or recipient, have autoimmune diseases like lupus or rheumatoid arthritis, or experience unexplained immune system issues. It helps guide decisions about compatibility or treatment plans.
What to Expect Before the Test
No special preparation is needed. You’ll provide a blood sample (serum or plasma) via a simple venipuncture. If you’re a donor, your sample may be tested alongside others for compatibility. Avoid alcohol for 24 hours before testing if instructed.
What the Test Results Mean
Results show whether antibodies against HLA-DR antigens are present. Elevated levels may indicate an immune response that could affect organ compatibility or autoimmune activity. Your provider will interpret results in the context of your medical history.
Common Conditions Linked to This Test
This test is critical for organ transplantation to prevent rejection. It may also help diagnose autoimmune diseases where the immune system mistakenly attacks the body’s own tissues, such as lupus or vasculitis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: Elevated HLA-DR antibody levels often signal an immune response that could interfere with organ function or autoimmune activity. Low or absent levels may indicate a compatible immune profile for transplantation or reduced autoimmune risk. Results guide personalized treatment plans, especially in transplant candidates or patients with suspected autoimmune disorders.
Short name
HLA-DR Antibody Screening
Frequently asked questions
What does a positive result mean for my health?
How long will I need to wait for results?
Can I take anything before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy