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Serum or Plasma Immunoassay for Anti-IgG Autoantibodies (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures certain antibodies in your blood that may target immunoglobulin G (IgG), a type of protein involved in immune responses. It helps identify potential autoimmune conditions where the body mistakenly attacks its own proteins.

Quick summary

["This screening may help detect autoimmune disorders by checking for unusual antibodies against IgG."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107916-9
Short code
HLA I IgG pre SerPl IA
Synonyms
HLA I IgG pre SerPl IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like chronic fatigue, joint pain, or unexplained rashes, or if you have a family history of autoimmune diseases. It could also be part of an evaluation for conditions like systemic lupus erythematosus (SLE) or mixed connective tissue disease.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If plasma is used instead of serum, you might be asked to avoid certain medications or foods for a short time to ensure accurate results.

What the Results Mean

Results are qualitative (positive or negative) rather than numeric. A positive screening result suggests the presence of unusual IgG autoantibodies, which may warrant further testing to confirm or investigate the underlying cause.

Common Conditions This Test Helps Identify

While not definitive, elevated or abnormal IgG autoantibodies can be associated with autoimmune diseases, including lupus, rheumatoid arthritis, or other connective tissue disorders. This test is often used as part of a broader diagnostic workup.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Autoantibody Screening

Frequently asked questions

What does a positive screening result mean?
A positive result means your blood contains unusual antibodies targeting IgG proteins, which may indicate an autoimmune response. This finding often requires further evaluation by a healthcare provider to determine the next steps, such as additional tests or monitoring.
Can I eat or drink anything before this test?
No specific diet or fasting is required for this test. However, if plasma is used, your provider may advise avoiding certain medications or supplements for a short time to ensure accurate results. Follow your healthcare provider’s instructions.
How long will it take to get my results?
Results are typically available within a few days to a couple of weeks, depending on lab processing times. Your healthcare provider will contact you once results are ready, so keep their contact information handy.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy