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Serum or Plasma Creatinine Concentration (Standard Method)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function by evaluating how well your kidneys remove waste from your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96271-2
Short code
hMSH3 Ag Ca spec Ql ImStn
Synonyms
hMSH3 Ag Ca spec Ql ImStn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
immune-stain
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Your Kidneys Matter

Your kidneys filter waste and extra fluids from your blood to keep your body balanced. Creatinine is a natural waste product that builds up when your kidneys aren’t working as they should. High levels can signal kidney problems, while low levels might indicate dehydration or other conditions.

What to Expect Before the Test

You may be asked to fast for a few hours before the test, but this isn’t always required. Bring any medications you’re currently taking. Avoid strenuous activity or heavy meals 24 hours before testing to get the most accurate results.

When This Test Is Ordered

Doctors order creatinine tests to monitor kidney health, diagnose kidney disease, check for dehydration, or evaluate conditions like heart failure or muscle disorders. It’s often part of a routine checkup or when symptoms like swelling, fatigue, or changes in urine appear.

What the Results Mean

Results are compared to a general reference range, but your actual values depend on factors like age, sex, and muscle mass. High levels may indicate poor kidney function, while very low levels could suggest dehydration or other health issues. Your doctor will discuss these results in detail.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Creatinine levels are a key indicator of kidney function. Elevated levels often signal reduced kidney filtration, which can lead to serious complications if untreated. It’s a non-invasive test that helps doctors track kidney health over time and adjust treatments accordingly.

Short name

Creatinine Level

Frequently asked questions

What causes creatinine levels to be high?
High creatinine levels can be caused by kidney disease, dehydration, severe muscle damage, or conditions that affect blood flow to the kidneys. Lifestyle factors like poor diet or chronic conditions (e.g., diabetes) may also play a role.
What should I do if my creatinine level is high?
If your test results show high creatinine, your doctor may recommend lifestyle changes (like reducing salt or staying hydrated), medications, or further tests to identify the cause. Follow their guidance closely to manage your health.
Can diet affect creatinine levels?
Yes, diet can influence creatinine levels indirectly. High-protein diets may temporarily raise levels, but your kidneys usually adjust over time. Avoiding excessive protein or staying hydrated can help maintain stable results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy