Total Protein with Albumin Ratio (Serum)
This test measures the proportion of albumin (a protein) relative to total protein in your blood serum, which can help assess protein balance and potential kidney or liver function issues.
["Understanding your protein balance may help identify health concerns like malnutrition or organ dysfunction."]
Key facts at a glance
- LOINC
- 72916-0
- Short code
- HNA 1b/1b Ab Ser Ql IA
- Synonyms
- HNA 1b/1b Ab Ser Ql IA
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Albumin is one of the most abundant proteins in your blood and plays a key role in maintaining fluid balance and transporting substances like hormones and medications. Total protein includes albumin plus other proteins like globulins. A ratio helps doctors evaluate how well your body produces and balances these proteins.
How the Test Works
Blood is drawn from a vein, typically in your arm, and sent to a lab. The test measures the concentration of albumin and total protein using standard laboratory techniques, such as immunoturbidimetry or similar methods.
Common Reasons for Testing
Doctors may order this test if you have symptoms like swelling (edema), unexplained weight loss, fatigue, or if they suspect conditions like liver disease, kidney problems, or malnutrition.
Preparing for Your Test
No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if instructed by your healthcare provider. Avoid smoking or consuming alcohol for a few hours before the draw.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Albumin-to-Protein Ratio
Frequently asked questions
A low albumin-to-protein ratio may indicate conditions like liver disease, kidney failure, or severe malnutrition, as these can reduce protein production or increase protein loss. High ratios are less common but could suggest dehydration or certain inflammatory conditions.
Will I need to do anything after the test? Follow-up care depends on your test results and your doctor’s recommendations. If you have concerns, contact your healthcare provider.
Is this test painful? Blood draws are generally quick and well-tolerated. Most people experience only mild discomfort or a brief pinch at the injection site.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy