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Human Neutrophil Antigen Type Blood Grouping (HNA Typing)

Published: August 9, 2026Updated: August 16, 2026

This test identifies specific antigens found on white blood cells called neutrophils, which can help determine compatibility for blood transfusions or organ transplants.

Quick summary

["HNA typing helps ensure safe blood or organ donations by matching antigens between donors and recipients."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72919-4
Short code
HNA 3 Gentyp Bld
Synonyms
HNA 3 Gentyp Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is HNA Typing Used For?

HNA typing is primarily used in blood transfusion medicine and organ transplantation to prevent adverse reactions. Certain HNA antigens can cause immune responses if mismatched, potentially leading to complications like transfusion reactions or graft rejection.

How Is the Test Performed?

A small blood sample is drawn from your arm. The sample is then tested using specialized laboratory techniques, such as immunoassay or electrophoresis, to detect the presence of specific HNA antigens on your neutrophils.

Why Might You Need This Test?

You may need HNA typing if you are a blood donor, a recipient of blood products, or a candidate for organ transplantation. It is also used in research or clinical studies involving blood compatibility.

What Does the Test Result Mean?

Results provide a profile of your HNA antigens, which can help healthcare providers determine compatibility for future blood transfusions or transplants. Exact interpretation depends on clinical context and may require consultation with a specialist.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HNA Typing

Frequently asked questions

Why do some people need HNA typing before blood donations?
Some individuals may be at higher risk of developing antibodies against certain HNA antigens if they have been previously transfused, received blood components, or had prior pregnancies. HNA typing helps identify these risks to prevent future adverse reactions.
How long does it take to get HNA typing results?
Test results are typically available within 1–3 business days, depending on laboratory processing times. Follow-up with your healthcare provider for interpretation and next steps.
Can HNA typing affect my routine blood tests?
No, HNA typing is a separate test focused specifically on neutrophil antigens. It does not interfere with other routine blood tests, but results may be used alongside other lab findings to guide clinical decisions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy