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Total Protein with Albumin/GLOBULIN Fraction (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein levels and breaks down the protein into albumin and globulin fractions, which help assess overall protein health and potential imbalances.

Quick summary

["Your blood proteins provide structure, transport nutrients, and support immune function—this test helps spot issues like malnutrition, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72911-1
Short code
HNA 4b/4b Ab Ser Ql IA
Synonyms
HNA 4b/4b Ab Ser Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Protein is vital for many bodily functions, including maintaining healthy tissues, transporting vitamins and minerals, and supporting your immune system. Your body produces two main types of protein in blood: albumin and globulins. Albumin helps keep fluids balanced in your bloodstream, while globulins include antibodies that fight infections. Abnormal levels can signal conditions like liver disease, kidney problems, or malnutrition.

How the Test Works

A small blood sample is drawn and analyzed to measure total protein concentration and the proportion of albumin versus globulin. The results help doctors identify whether protein levels are too high or too low, or if one type of protein is disproportionately affected.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like chronic liver disease (where albumin production may drop), kidney disease (where protein may leak into urine), severe infections, or malnutrition. It may also be checked after surgeries or treatments that affect protein synthesis.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your doctor specifies it. Wear a comfortable shirt for easy access to your arm for the blood draw.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Protein Profile

Frequently asked questions

What might abnormal results mean?
Low total protein or albumin levels could indicate liver disease, kidney problems, severe infections, or malnutrition. High globulin levels might suggest chronic infections, autoimmune diseases, or certain cancers. Your doctor will discuss these findings in detail with you.
How often will I need this test?
Your doctor may order this test periodically if you have ongoing health conditions like liver disease, kidney disease, or immune disorders. It may also be part of routine check-ups or after treatments that affect protein levels.
Can I eat or drink before this test?
Typically, no fasting is required unless your doctor instructs otherwise. Always follow your healthcare provider’s specific instructions for the best results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy