Total Protein with Albumin/GLOBULIN Fraction (Serum)
This test measures your blood’s total protein levels and breaks down the protein into albumin and globulin fractions, which help assess overall protein health and potential imbalances.
["Your blood proteins provide structure, transport nutrients, and support immune function—this test helps spot issues like malnutrition, liver disease, or kidney problems."]
Key facts at a glance
- LOINC
- 72911-1
- Short code
- HNA 4b/4b Ab Ser Ql IA
- Synonyms
- HNA 4b/4b Ab Ser Ql IA
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Protein is vital for many bodily functions, including maintaining healthy tissues, transporting vitamins and minerals, and supporting your immune system. Your body produces two main types of protein in blood: albumin and globulins. Albumin helps keep fluids balanced in your bloodstream, while globulins include antibodies that fight infections. Abnormal levels can signal conditions like liver disease, kidney problems, or malnutrition.
How the Test Works
A small blood sample is drawn and analyzed to measure total protein concentration and the proportion of albumin versus globulin. The results help doctors identify whether protein levels are too high or too low, or if one type of protein is disproportionately affected.
Common Conditions Monitored
This test is often used to diagnose or monitor conditions like chronic liver disease (where albumin production may drop), kidney disease (where protein may leak into urine), severe infections, or malnutrition. It may also be checked after surgeries or treatments that affect protein synthesis.
What to Expect Before the Test
No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your doctor specifies it. Wear a comfortable shirt for easy access to your arm for the blood draw.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Total Protein Profile
Frequently asked questions
What might abnormal results mean?
How often will I need this test?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy