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Human Neutrophil Antigen Type Blood Group Determination (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test identifies specific antigens found on white blood cells, particularly neutrophils, which can affect blood compatibility during transfusions.

Quick summary

["This helps ensure safe blood matching for transfusions by detecting rare antigens that may cause adverse reactions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72918-6
Short code
HNA 4 Gentyp Bld
Synonyms
HNA 4 Gentyp Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Neutrophil antigens (HNAs) are proteins on the surface of white blood cells. While most blood types are well-matched, some rare HNAs can cause unexpected reactions if transfused. This test checks for these rare antigens to prevent complications like allergic reactions or hemolysis during blood transfusions.

How the Test Works

Blood is drawn and tested using immunoassay methods to detect the presence of specific HNA antigens. If antigens are found, they are classified to guide blood compatibility decisions.

When You Might Need This Test

This test is typically ordered for patients who have had unexpected transfusion reactions, those with rare blood types, or individuals undergoing planned transfusions where HNA compatibility is a concern.

Common Uses

HNA typing is primarily used to refine blood donor selection for patients with known sensitivities or rare blood types, reducing the risk of transfusion-related adverse events.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HNA Typing

Frequently asked questions

What are the normal results for this test?
Results are qualitative (positive or negative) for each HNA antigen tested. No specific reference ranges apply, as the focus is on antigen presence rather than numeric values.
How long does it take to get my test results?
Results are usually available within 24 to 48 hours, depending on lab processing times and testing complexity.
Can I donate blood if this test is positive?
If positive for certain HNA antigens, your blood may not be compatible with all donors. Your healthcare provider will discuss blood donation restrictions with you based on your results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy