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Human Neutrophil Antigen Type Blood Grouping (HNA Typing)

Published: August 9, 2026Updated: August 16, 2026

This test identifies specific antigens found on white blood cells, particularly neutrophils, which can affect blood compatibility during transfusions.

Quick summary

["This test helps ensure safe blood matching for transfusions by checking for rare antigens that may cause adverse reactions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
72917-8
Short code
HNA 5 Gentyp Bld
Synonyms
HNA 5 Gentyp Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may recommend HNA typing if you’re scheduled for a blood transfusion, especially if you have a history of severe allergic reactions or rare blood types. It helps prevent complications by confirming compatibility with donor blood.

What Does the Test Involve?

A small blood sample is drawn from your arm. The sample is tested using specialized techniques to detect the presence of specific HNA antigens on your neutrophils. Results are qualitative (present or absent).

How Long Does It Take to Get Results?

Test results are typically available within 24 to 48 hours, depending on laboratory processing times. Your doctor will discuss the findings with you during follow-up.

What Are Common Uses?

HNA typing is primarily used in transfusion medicine to assess compatibility for patients with rare blood types or those at higher risk of transfusion reactions. It may also be used in research or specialized clinical scenarios.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HNA Blood Grouping

Frequently asked questions

What does HNA typing measure?
HNA typing detects the presence or absence of specific antigens (like HNA-1, HNA-2, etc.) on your neutrophils, which are white blood cells. These antigens can vary between individuals and may affect blood compatibility.
How often is this test needed?
This test is usually performed only when you need a blood transfusion, such as before surgery, for severe anemia, or in cases where your blood type is rare or unknown. Your doctor will determine if testing is necessary based on your medical history and situation.
Can HNA typing affect my routine blood tests?
No, HNA typing is a separate test from routine blood work (like complete blood counts or electrolytes). It focuses specifically on neutrophil antigens and is not part of standard screening unless indicated for transfusion purposes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy