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Hemoglobin A1c (HbA1c) with 24-hour urine collection for total urinary protein excretion

Published: August 9, 2026Updated: August 16, 2026

This test measures your average blood sugar levels over the past 2–3 months and checks how much protein is lost in urine over 24 hours, often linked to kidney function or diabetes management.

Quick summary

["Helps track long-term blood sugar control and kidney health in people with diabetes or kidney concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104488-2
Short code
HNA rprt Doc
Synonyms
HNA rprt Doc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86592
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The **HbA1c** test reflects your average blood sugar levels over time by measuring the percentage of hemoglobin (the oxygen-carrying protein in red blood cells) that is coated with sugar. This provides a snapshot of how well your blood sugar has been controlled over months, rather than just recent days. Higher levels may indicate poor diabetes management or undiagnosed diabetes.

Why Urine Protein Is Included

The 24-hour urine protein test assesses how much protein your kidneys filter into your urine. Elevated protein levels can signal kidney damage or disease, especially in people with diabetes. Together, these tests help doctors monitor both blood sugar control and kidney function in people at risk for complications.

When This Test Is Ordered

Your doctor may order this test if you have diabetes, prediabetes, or symptoms like frequent urination, swelling, or fatigue. It’s also used to check kidney health in people with diabetes or those with high blood pressure or family history of kidney disease.

What to Expect Before the Test

For the urine protein part, you’ll collect all urine for 24 hours in a special container. For the HbA1c, no special prep is needed, but you may be asked to fast or avoid certain medications. Follow your doctor’s instructions carefully to ensure accurate results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HbA1c + 24-hour urine protein

Frequently asked questions

Why might my HbA1c be higher than expected?
Several factors could affect HbA1c, including recent illness, stress, certain medications (like blood thinners), or blood loss (e.g., from heavy periods). If you suspect an issue, discuss it with your doctor—they may review your recent blood sugar trends or adjust test timing.
Does diet or exercise affect HbA1c results?
Diet and exercise influence short-term blood sugar but don’t change HbA1c levels directly. However, improving these habits can help lower HbA1c over time. Your doctor may recommend lifestyle changes if your results are consistently high.
What if my urine protein is elevated?
Elevated urine protein may signal early kidney problems, especially if you have diabetes. Your doctor will likely order follow-up tests (like kidney function blood tests) to assess kidney health. Lifestyle changes, such as controlling blood pressure and blood sugar, can help protect your kidneys.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy