Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Multiplex Genetic Testing (Blood)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a strong family history of colorectal cancer, particularly multiple cases in close relatives, or if you have a personal history of certain cancers (like endometrial, ovarian, or small bowel cancers). It may also be suggested if you were diagnosed with colorectal cancer before age 50 or have other HNPCC-related symptoms.

What to Expect During the Test

A simple blood draw is used to collect a small sample. The lab will analyze your DNA for known mutations associated with HNPCC. Results are typically available within 2–4 weeks, depending on the lab’s processing time.

Understanding Your Results

Results can be categorized as negative (no mutations found), positive (mutations detected), or uncertain (limited genetic information). A positive result means you carry a mutation linked to HNPCC and may need closer monitoring or preventive strategies.

What Your Results Mean for You

If you test positive, your provider will discuss next steps, such as increased cancer screenings (e.g., colonoscopy at an earlier age), family counseling, or genetic counseling to manage risk and support you.