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Homocysteine

Published: July 27, 2026Updated: August 25, 2026

Homocysteine is an amino acid that is measured to assess cardiovascular risk and potential deficiencies in vitamins B6, B12, and folate.

Quick summary

Homocysteine levels help evaluate cardiovascular health and nutritional deficiencies.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
μmol/L
Clinical utility
screening
Result kind
quantitative
FDA-cleared
Abbott Homocysteine, Roche Homocysteine, Siemens Homocysteine
interpretation: {"text":"5–15 μmol/L: Homocysteine levels within this range are considered normal and indicative of a lower cardiovascular risk.","label":"Normal"}; {"text":">15 μmol/L: Levels above 15 μmol/L may suggest an increased risk of cardiovascular disease and may warrant further investigation.","label":"Elevated"}

Homocysteine is an amino acid produced during the metabolism of methionine, an essential amino acid obtained from dietary protein. Elevated levels of homocysteine in the blood, known as hyperhomocysteinemia, have been associated with an increased risk of cardiovascular diseases such as heart attack and stroke.

The measurement of homocysteine levels is often used as a screening tool to identify individuals who may be at risk for cardiovascular events. It is also used to monitor the effectiveness of treatment strategies aimed at reducing homocysteine levels, such as vitamin supplementation.

Normal homocysteine levels are typically between 5–15 μmol/L. Levels above this range may indicate a need for further evaluation and potential intervention to reduce cardiovascular risk.

Frequently asked questions

What factors can cause elevated homocysteine levels?
Factors such as vitamin B6, B12, or folate deficiencies, certain medications, and genetic conditions can lead to elevated homocysteine levels.
How can I lower my homocysteine levels?
Consuming a diet rich in folate, vitamin B6, and vitamin B12, or taking supplements, can help lower homocysteine levels. Lifestyle changes such as quitting smoking and increasing physical activity may also be beneficial.
  1. 1
    Mayo Clinic: Homocysteine TestSource
  2. 2
    American Heart Association: HomocysteineSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy