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Total Protein in Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood serum, which includes important proteins like albumin and globulins that help maintain fluid balance, support immunity, and transport nutrients.

Quick summary

["Your blood protein levels can indicate overall health, hydration status, or potential medical conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39550-9
Short code
Horse Dander IgE/IgE total %
Synonyms
Horse Dander IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes both albumin and globulin proteins. Albumin helps regulate blood pressure and fluid balance, while globulins support immune function and transport substances like hormones and metals. Together, they reflect your body’s protein production and health of organs like the liver and kidneys.

Why Might Your Doctor Order This Test?

Doctors may check total protein levels if you have symptoms like swelling, unexplained weight loss, fatigue, or signs of liver/kidney disease. It can also help diagnose conditions like malnutrition, infections, or certain cancers.

How Is This Test Performed?

A small blood sample is drawn from your arm, and the serum (liquid part after clotting) is analyzed to measure protein concentration using automated laboratory methods.

What Are Common Results and Next Steps?

Results may be compared to your baseline or general reference ranges to identify imbalances. Low levels might suggest malnutrition or liver/kidney issues, while high levels could indicate dehydration, inflammation, or certain diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein

Frequently asked questions

What causes low total protein levels?
Low total protein can result from conditions like malnutrition, liver disease, kidney disease, or severe infections. It may also occur if your body is losing protein through wounds, burns, or excessive sweating.
What causes high total protein levels?
High total protein can be due to dehydration, certain cancers (like multiple myeloma), chronic inflammation, or conditions that increase globulin production (e.g., autoimmune diseases). Rarely, it may also reflect lab errors or overestimation from clotting factors.
How often should I get this test?
Your doctor will determine the frequency based on your symptoms, medical history, or ongoing health needs. Routine checks may not be necessary unless you have risk factors or conditions linked to protein imbalances.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy