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Hemoglobin A1c (HbA1c) with 24-hour urine collection for albumin-to-creatinine ratio (UACR) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures your long-term blood sugar control and checks for early kidney damage by comparing hemoglobin A1c levels with urine albumin levels.

Quick summary

["Assesses diabetes management and kidney health in a single profile."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
68354-0
Short code
HOSPICEPRIORTODEATH
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters for Diabetes Care

HbA1c reflects average blood sugar levels over the past 2–3 months, helping doctors track diabetes progression or response to treatment. Elevated levels may indicate poor control, while consistent values show effective management.

Understanding Kidney Function in Diabetes

The urine albumin-to-creatinine ratio (UACR) detects early kidney damage by measuring albumin (a protein) in urine relative to creatinine (a waste product). High UACR suggests kidney strain, often linked to diabetes.

How the Test Works

Your blood sample is tested for HbA1c via immunoassay, while urine is analyzed for albumin and creatinine using standardized methods. Results are compared to identify trends in blood sugar and kidney health.

What Results Mean for Your Health

HbA1c results alone show blood sugar trends, while UACR results highlight kidney exposure to high glucose. Together, they provide a fuller picture of diabetes-related risks.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: HbA1c and UACR together help identify diabetes-related complications early. High HbA1c with normal UACR may indicate poor glucose control, while high UACR alone suggests kidney vulnerability, even if blood sugar is stable.

Short name

HbA1c + UACR profile

Frequently asked questions

Why did my doctor order this test?
Your doctor may recommend this test if you have diabetes, kidney concerns, or are at risk for both. It helps monitor long-term effects of diabetes and kidney health in one profile.
What do abnormal results mean?
Abnormal HbA1c may signal uncontrolled diabetes, while abnormal UACR suggests kidney strain. Both require follow-up with your healthcare team to adjust treatment plans.
Can I fast before this test?
No fasting is required for HbA1c, but follow your doctor’s instructions for urine collection (e.g., timing or sample type). Always confirm with your lab or provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy