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Cow's Milk-Specific IgE Antibody, 12-Month Phenotype

Published: August 9, 2026Updated: August 16, 2026

Measures IgE antibodies directed against cow's milk proteins to help evaluate a possible milk allergy around 12 months of age.

Quick summary

["A positive result supports cow's milk sensitization but must be interpreted with symptoms and medical history."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61559-1
Short code
How often skim milk in 12Mo PhenX
Synonyms
How often skim milk in 12Mo PhenX
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
phenx
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures IgE antibodies directed against cow's milk proteins. It may be used as part of an evaluation for cow's milk allergy in a child around 12 months of age.

Why might I need this test?

It may be ordered when a child has symptoms such as hives, swelling, vomiting, abdominal discomfort, wheezing, or eczema that could be related to cow's milk. The result helps assess whether the immune system is sensitized to milk proteins.

How is the test performed?

A blood sample is analyzed in a laboratory for allergen-specific IgE using an immunoassay-based method. The laboratory report identifies the type or amount of antibody detected.

How do I prepare for the test?

No special preparation is usually required. Continue prescribed diets and medications unless your clinician gives different instructions, and tell the healthcare provider about recent allergic reactions, eczema, or other illnesses.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Detectable cow's milk-specific IgE indicates immune sensitization to milk proteins and may support a diagnosis of IgE-mediated cow's milk allergy. Results must be interpreted alongside symptoms, growth, medical history, and sometimes oral food challenge because sensitization does not always mean clinically significant allergy. Antibody levels can also change with age, particularly during the first few years of life.

Short name

Cow's milk-specific IgE

Frequently asked questions

Does a positive result mean my child is allergic to milk?
Not necessarily. It shows that milk-specific IgE is present, but some children have sensitization without symptoms. Your clinician will interpret the result in the context of your child's reactions and history.
Can my child continue eating milk while waiting for the result?
Do not make major dietary changes without medical advice. If your child has had a severe reaction, hives, breathing difficulty, or faintness, contact a healthcare professional promptly and avoid the suspected trigger until advised.
Why is age important when interpreting this test?
Milk-specific IgE levels often decrease as children grow, and the relationship between a result and symptoms can change with age. Testing around 12 months should therefore be interpreted using age-appropriate clinical guidance.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy