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Human Immunodeficiency Virus (HIV) Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the human immunodeficiency virus (HIV), which your body makes in response to infection. It helps determine if you’ve been exposed to HIV.

Quick summary

["An HIV antibody screen detects potential infection with HIV, the virus that can lead to AIDS."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38400-8
Short code
HPIV1+2+3 Ab Ser Ql
Synonyms
HPIV1+2+3 Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

A small blood sample is taken from your arm and sent to a lab. The serum or plasma is tested for HIV antibodies using an immunoassay method, which detects the presence of these antibodies that your immune system produces after exposure to HIV.

What to Expect Before the Test

No special preparation is needed. You may have some mild discomfort from the needle, but it usually goes away quickly. If you’re pregnant, breastfeeding, or have a bleeding disorder, let your provider know before the test.

What to Expect After the Test

You can return to your normal activities right after the test. There’s usually no downtime, but watch for signs of bruising or swelling at the injection site. If you experience excessive bleeding or pain, contact your provider.

Interpreting Your Results

This test is a screening tool. A positive result means your blood contains HIV antibodies, suggesting past or current infection. A negative result means no detectable antibodies were found, but HIV could still be present in very early stages. Further testing (like a confirmatory HIV antibody test or viral load test) is needed for a definitive diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HIV Antibody Screen (Serum/Plasma)

Frequently asked questions

How soon can I get my results?
Results from this screening test are typically available within 1 to 3 business days. However, confirmatory testing may take longer, so follow up with your provider for next steps.
What does a positive result mean?
A positive result on this screening test means your blood contains HIV antibodies, which could indicate past or current infection. You’ll need further testing to confirm the diagnosis and determine if treatment is needed.
Can I still have HIV if my screening test is negative?
Yes, it’s possible. HIV testing can miss infections in the very early stages (window period), which can last up to several weeks. If you’re at risk, consider repeat testing or other diagnostic tests to check for the virus itself, not just antibodies.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy