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Human Immunodeficiency Virus Type 2 Immunoglobulin M Antibody (IgM) - Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of Immunoglobulin M (IgM) antibodies against Human Immunodeficiency Virus Type 2 (HIV-2) in your blood. IgM antibodies are often detected early in infection but may decline over time as other antibody types (like IgG) develop.

Quick summary

["This test helps detect early HIV-2 infection by identifying IgM antibodies, which can appear sooner than other markers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110201-1
Short code
HPIV2 IgM Msmt Ser
Synonyms
HPIV2 IgM Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms suggestive of HIV-2 infection (such as fever, fatigue, or swollen lymph nodes), have risk factors for HIV-2 (e.g., exposure in regions where HIV-2 is more common), or if you’re part of a group at higher risk. It may also be used as part of a diagnostic workup for suspected HIV infection, especially if HIV-1 testing is inconclusive or if HIV-2 is suspected.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm to draw a blood sample. If you’re nervous, let your healthcare provider know—they can help make the process more comfortable.

What to Expect During the Test

The blood sample will be taken from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood is then sent to a lab for testing.

What the Results Mean

Results can be positive (indicating current or past HIV-2 infection), negative (no detectable IgM antibodies), or inconclusive. A positive result means further testing (like HIV-2 viral load or antibody confirmation) is usually needed to confirm diagnosis. A negative result means no IgM antibodies were found at the time of testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Detecting HIV-2 early is important because it allows for timely medical intervention, which can help manage symptoms and prevent complications. IgM antibodies are useful for identifying acute or early-stage infection, though they may not persist long-term. If you test positive, your healthcare provider will guide you on next steps, including additional testing and treatment options.

Short name

IgM Antibody to HIV-2

Frequently asked questions

What does a positive result mean?
A positive result suggests the presence of IgM antibodies against HIV-2, which may indicate past or current infection. This result will need to be confirmed with additional tests to determine if HIV-2 is actively present in your body.
Can I get HIV-2 from sharing needles or having unprotected sex?
HIV-2 can be transmitted through blood, semen, vaginal fluids, or breast milk. Sharing needles or having unprotected sex with someone infected increases your risk. If you’ve had these exposures, discuss prevention strategies with your healthcare provider.
How long after exposure might I test positive for IgM antibodies?
IgM antibodies against HIV-2 may appear within weeks to months after exposure, but timing varies. Some people develop detectable levels sooner, while others may take longer. Testing at multiple intervals after exposure is often recommended for accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy