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Placental Human Chorionic Gonadotropin (hCG) Concentration in Amniotic Fluid

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of human chorionic gonadotropin (hCG), a hormone produced by the placenta, in amniotic fluid. It helps assess fetal development and detect potential complications during pregnancy.

Quick summary

["Measures placental hormone levels to support early pregnancy monitoring."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55894-0
Short code
HPRT/APRT Placenta-cRto
Synonyms
HPRT/APRT Placenta-cRto
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you are at higher risk for pregnancy complications, such as gestational diabetes, preeclampsia, or fetal growth issues. It can also be used to monitor multiple pregnancies (twins, triplets) or when there are concerns about fetal well-being.

How the Test Works

Amniotic fluid is collected through a procedure called an amniocentesis, where a small amount of fluid is taken from around the fetus. The hCG levels in this fluid are then measured to evaluate fetal development and health.

Sample Collection and Preparation

The test requires a specialized procedure to collect amniotic fluid, which is usually done under ultrasound guidance. This fluid is sent to a lab for analysis to determine the hCG concentration.

What to Expect Before the Test

You may need to prepare by fasting for a short period before the procedure, depending on your healthcare provider’s instructions. Inform your provider about any medications or supplements you’re taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated hCG levels in amniotic fluid may indicate a healthy pregnancy, especially in early stages. However, very high or abnormal levels can sometimes suggest conditions like molar pregnancy or multiple gestations. Low levels may raise concerns about fetal development or pregnancy loss.

Short name

Amniotic fluid hCG test

Frequently asked questions

When might I need this test?
This test is typically recommended during the second trimester or in cases of high-risk pregnancies, such as those with prior complications or genetic concerns.
Is the procedure painful?
The procedure itself involves a small needle inserted through your abdomen, which may cause mild discomfort or cramping. You’ll likely feel pressure but should not experience significant pain.
How long will I need to rest after the test?
You’ll need to rest for a short period, usually a few hours, to allow your body to recover from the procedure. Follow your healthcare provider’s instructions for any specific rest or activity recommendations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy