Genetic mutation screening for hereditary pancreatitis (HPS) via whole blood DNA analysis
This test checks for specific genetic mutations linked to hereditary pancreatitis, a condition causing chronic inflammation of the pancreas that may run in families.
["Determining if you may inherit a risk for hereditary pancreatitis through genetic testing."]
Key facts at a glance
- LOINC
- 101964-5
- Short code
- HPS3 gene Mut Anl Bld/T
- Synonyms
- HPS3 gene Mut Anl Bld/T
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your doctor may recommend this test if you or a close family member have a history of pancreatitis, abdominal pain, or other symptoms associated with hereditary pancreatitis. It’s also used for genetic counseling and risk assessment in families with a known hereditary pattern.
What to Expect Before the Test
No special preparation is needed. A small blood sample will be taken from your arm, similar to a routine blood draw. You may feel slight discomfort, but it usually lasts only a few seconds.
What the Test Results Mean
Results will identify whether you carry the specific genetic mutations (e.g., *PRSS1*, *SPINK1*, or *CFTR*) linked to hereditary pancreatitis. Positive results indicate a higher risk of developing the condition, which can guide prevention and management strategies.
How Results Are Used
If you test positive, your doctor may recommend lifestyle changes, dietary adjustments, or monitoring for early signs of pancreatitis. Genetic counseling can also help you understand your risk for family members.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
HPS Mutation Blood Test
Frequently asked questions
This test helps identify genetic predispositions that may not show symptoms until adulthood. Early detection allows for proactive management, reducing potential complications like pancreatic cancer or chronic organ damage.
A positive result means you may pass these mutations to your children. Genetic counseling can help explain risks to family members and guide decisions about testing or preventive measures.
No fasting is required for this blood test. Unlike some other tests, dietary restrictions do not apply.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy