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High-Sensitivity C-Reactive Protein (hsCRP) - Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation, often used to assess low-grade inflammation or risk of future health issues.

Quick summary

["hsCRP helps track subtle inflammation that may not show up with other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
11175-7
Short code
H sativum IgE Qn
Synonyms
H sativum IgE Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hsCRP Used For?

hsCRP is commonly ordered to evaluate cardiovascular risk, monitor chronic conditions like arthritis or heart disease, or check for signs of inflammation after surgery or injury. It may also be used in research or screening programs where standard CRP levels aren’t sensitive enough.

How Is the Test Performed?

A small blood sample is drawn from your arm. The blood is processed into either serum (after clotting) or plasma (using an anticoagulant) and sent to a lab for analysis. The test typically requires fasting, though this isn’t always mandatory.

What Does a High or Low Result Mean?

Results are interpreted based on clinical context, not absolute numbers. High hsCRP levels may indicate inflammation, while low levels suggest minimal inflammation. Your doctor will consider your overall health, symptoms, and other test results to interpret the meaning.

Common Reasons for Testing

Your doctor may order hsCRP to assess cardiovascular health, monitor chronic inflammatory conditions (e.g., rheumatoid arthritis), evaluate post-surgical recovery, or as part of a general health screening if inflammation is suspected.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hsCRP

Frequently asked questions

Why might my doctor order this test?
Your doctor may order hsCRP to check for inflammation in your body, especially if you have conditions like heart disease, arthritis, or other chronic illnesses. It can also help assess your risk for future health problems or monitor how well you’re responding to treatment.
What are typical reference ranges?
There isn’t a single standard reference range for hsCRP because it varies by lab, patient factors, and clinical context. Most labs use a range of 0 to 3 mg/L as a general guideline, but your results will be discussed with your doctor based on your specific situation.
Can lifestyle changes affect hsCRP levels?
Yes, lifestyle factors like diet, exercise, smoking, and stress can influence inflammation levels. Eating a heart-healthy diet, staying active, and avoiding smoking may help lower hsCRP levels over time, but results depend on overall health and medical treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy