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Herpes Simplex Virus Type 1 and Type 2 Antibody Screening (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to herpes simplex virus types 1 and 2, which can help determine if your body has been exposed to these viruses.

Quick summary

["Helps identify past exposure to common cold sore viruses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35875-4
Short code
HSV1+2 Ab CSF-aCnc
Synonyms
HSV1+2 Ab CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects antibodies produced by your immune system in response to exposure to herpes simplex virus (HSV) types 1 and 2. Antibodies are proteins your body makes to fight infections. This test uses an immunoassay method to measure these antibodies in your serum or plasma.

Why It’s Ordered

Your healthcare provider may order this test if you have symptoms like sores, fever blisters, or if you have a history of recurrent infections. It can also be used for screening in certain populations or during pregnancy to assess risk.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The blood is processed to separate serum or plasma, which is then analyzed in a lab.

What to Expect Before the Test

No special preparation is needed, but inform your provider if you are on blood-thinning medications or have a bleeding disorder. Avoid alcohol before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate past exposure to HSV, meaning your body has already encountered the virus. This does not mean you are currently infected but may be at risk for outbreaks. Negative results suggest no detectable antibodies, meaning either you have never been exposed or the test was taken too early after exposure. This test is not used to diagnose active infections but can help guide further evaluation if needed.

Short name

HSV Antibody Screen

Frequently asked questions

How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on lab processing times.
What does a positive result mean?
A positive result means your body has produced antibodies to HSV, indicating past exposure. This does not confirm an active infection but may suggest a higher risk of outbreaks or transmission if applicable.
Can this test be used to diagnose a current HSV infection?
No, this test is for detecting past exposure. For diagnosing an active infection, your healthcare provider may order additional tests or clinical evaluation based on symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy