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Herpes Simplex Virus Type 1 Antibody, Qualitative (IgG and IgM) - Serology

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies against the herpes simplex virus type 1 (HSV-1), a common virus that can cause cold sores and other infections.

Quick summary

["Determines if your body has ever been exposed to HSV-1, which may help diagnose past or potential future infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44479-4
Short code
HSV1+2 Ab CSF Ql
Synonyms
HSV1+2 Ab CSF Ql
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms like cold sores, recurrent mouth ulcers, or if you’ve been exposed to someone with HSV-1. It can also be used to confirm a diagnosis in certain clinical scenarios, such as evaluating recurrent infections or assessing immune response after vaccination.

What to Expect Before the Test

No special preparation is needed. You’ll likely have a simple blood draw from a vein in your arm. If you’re concerned about discomfort, let your healthcare provider know.

What the Results Mean

Positive results indicate your body has produced antibodies against HSV-1, suggesting past infection. Negative results mean no detectable antibodies were found at this time. This does not rule out current infection, as antibodies may take time to develop.

Common Reasons for Testing

This test helps confirm a diagnosis of past HSV-1 infection, assesses immune response, or guides management of recurrent outbreaks. It’s not typically used for diagnosing active infections, which would require clinical correlation with symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 Antibody Screen/Confirm

Frequently asked questions

What does a positive result mean?
A positive result means your body has likely been exposed to HSV-1 at some point. This does not indicate whether you currently have an active infection. If you have symptoms like cold sores, your doctor may recommend further evaluation.
Can this test detect active HSV-1 infection?
No, this test only detects antibodies, which develop after infection. For diagnosing active infection, your doctor may use clinical judgment, symptom assessment, or other tests like viral culture or PCR.
Is there a difference between HSV-1 and HSV-2 antibodies?
Yes, this test specifically checks for HSV-1 antibodies. HSV-2 antibodies are tested separately and indicate infection with herpes simplex virus type 2, which often causes genital herpes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy