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Herpes Simplex Virus Type 1 Antibody (IgG) with Qualitative Immunoassay (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures your body’s immune response to herpes simplex virus type 1 (HSV-1), which can cause cold sores and other infections. It detects IgG antibodies, which develop after initial infection and remain in your system for long-term protection.

Quick summary

["This test helps assess past exposure to HSV-1 and supports diagnosis or monitoring of chronic infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90229-6
Short code
HSV 1+2 Ab.IgG & IgM panel SerPl
Synonyms
HSV 1+2 Ab.IgG & IgM panel SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms of HSV-1 infection (e.g., recurrent cold sores), if you’ve had close contact with someone with HSV-1, or if you’re evaluating immune function or recurrent infections. It may also be used in research or screening contexts where HSV-1 exposure is suspected.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (either serum or plasma) via a simple venipuncture. The test is typically done in a lab setting and results are usually available within a few days.

What the Test Results Mean

A positive result indicates the presence of IgG antibodies, suggesting past exposure to HSV-1. This does not confirm an active infection but indicates your immune system has encountered the virus. A negative result means no detectable antibodies were found, which may mean you’ve never been exposed or the test was taken too soon after exposure.

Common Reasons for Testing

This test is often used to diagnose or rule out HSV-1 infection in individuals with recurrent cold sores, to screen for latent infection in asymptomatic individuals, or to assess immune status in certain clinical scenarios.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HSV-1 IgG Antibody (Serum/Plasma)

Frequently asked questions

How does this test differ from HSV-1 IgM testing?
This IgG test measures long-term antibodies developed after initial infection. IgM antibodies, which appear earlier in infection, are typically used to detect recent or acute HSV-1 exposure. IgG alone can’t distinguish between past infection and immunity versus current infection.
Can I get this test if I’m currently experiencing symptoms of HSV-1?
While this IgG test can’t confirm an active infection, it may still be useful if symptoms are recurrent or if you’re unsure about past exposure. For active infection, your provider may order additional tests like viral culture or PCR to identify the virus itself.
What if my test results are positive but I’ve never had cold sores?
A positive IgG result means your body has encountered HSV-1 at some point, even if symptoms were mild or absent. Many people are infected with HSV-1 without knowing it, and the virus can lie dormant in your nerves. This test doesn’t indicate whether you’re currently infectious or if symptoms will develop later.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy