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Herpes Simplex Virus Type 1 and Type 2 Antibody Titers (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This blood test measures the levels of antibodies against herpes simplex virus types 1 and 2, which can help determine if you’ve been exposed to these viruses.

Quick summary

["This test helps assess past infection and immune response to herpes viruses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43033-0
Short code
HSV1+2 Ab Titr CSF
Synonyms
HSV1+2 Ab Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects antibodies produced by your immune system in response to herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Antibodies are proteins your body makes to fight infections. This test is typically done to check for past exposure rather than active infection.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms or a history of herpes, if you’re at risk for herpes (e.g., due to sexual history), or if you’re planning pregnancy and want to assess potential exposure.

Sample Collection and Preparation

A blood sample is taken from a vein in your arm. The blood is sent to a lab for processing, where it is tested for the presence of antibodies against HSV-1 and HSV-2 using an immunoassay method.

What to Expect Before the Test

No special preparation is needed for this test. You may have some mild discomfort or bruising at the injection site, but this usually goes away quickly.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate past exposure to HSV-1 or HSV-2, meaning your body has developed immunity. However, this does not guarantee you won’t develop symptoms later. If you have symptoms like sores, pain, or flu-like illness, this test alone won’t confirm an active infection—additional testing may be needed. Results can also help guide treatment decisions or inform preventive measures.

Short name

HSV Antibody Test

Frequently asked questions

How long does it take to get results?
Results are typically available within 1 to 2 weeks, depending on the lab’s processing time.
What does a positive result mean?
A positive result means your body has detected antibodies to HSV-1 or HSV-2, suggesting you’ve been exposed to the virus at some point. This does not indicate whether you currently have an active infection.
Can this test be used to diagnose active herpes?
No, this test is primarily for detecting past exposure. For diagnosing active herpes, your healthcare provider may recommend additional tests, such as viral culture or PCR testing, depending on symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy