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Herpes Simplex Virus Type 1 Antibody, Qualitative (IgG) by Probe-Based Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the herpes simplex virus type 1 (HSV-1), a common virus that can cause cold sores and other infections. It helps determine if your immune system has been exposed to HSV-1.

Quick summary

["This test checks for past exposure to HSV-1, not whether you currently have an active infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49385-8
Short code
HSV1+2 DNA # Amn NAA+probe
Synonyms
HSV1+2 DNA # Amn NAA+probe
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test measures the presence of IgG antibodies against HSV-1. These antibodies develop after your body has been exposed to the virus, usually months or years after initial infection. This is a qualitative test, meaning it only tells you whether antibodies are present or not, rather than how much.

Why Might You Need This Test?

Doctors may order this test if you have a history of cold sores or other HSV-1-related symptoms, if you have concerns about recurrent infections, or if you are planning a pregnancy and need to assess potential risks. It can also be used in certain research or screening contexts.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The sample is then processed and tested using a probe-based immunoassay, which detects specific antibodies in your blood. Results are typically available within a few days.

What Are Possible Results?

The test result will be either positive (indicating the presence of HSV-1 antibodies) or negative (indicating no detectable antibodies). A positive result suggests past exposure to HSV-1, but does not confirm an active infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 Antibody (IgG) Qualitative

Frequently asked questions

What does a positive result mean?
A positive result means your body has produced antibodies against HSV-1, suggesting you have been exposed to the virus at some point. This does not mean you currently have an active infection, but it confirms your immune system has encountered the virus.
Can this test be used to diagnose an active HSV-1 infection?
No, this qualitative antibody test is not used to diagnose an active infection. If you suspect you have an active HSV-1 infection, your doctor may recommend other tests, such as viral culture or PCR testing, which can detect the virus itself.
Is this test the same as a cold sore test?
No, this test measures antibodies to HSV-1, indicating past exposure. A cold sore is an active infection of the virus, which would require different types of testing to diagnose.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy