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Herpes Simplex Virus Type 1 Antibody, IgG (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies in your blood that your immune system produces in response to the herpes simplex virus type 1 (HSV-1), which can cause cold sores and other infections.

Quick summary

["Detects past exposure to HSV-1, helping confirm infection history or monitor immune response."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58414-4
Short code
HSV1+2 DNA Amn Ql NAA+probe
Synonyms
HSV1+2 DNA Amn Ql NAA+probe
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like cold sores, recurrent mouth ulcers, or if you’ve been exposed to someone with HSV-1. It can also be used to diagnose infections in individuals with weakened immune systems or to assess long-term immunity after vaccination or treatment.

What to Expect Before the Test

No special preparation is needed. A blood sample will be taken from a vein in your arm by a healthcare professional. You may feel a slight pinch, but it usually doesn’t cause discomfort.

What the Test Results Mean

Positive results indicate your body has produced antibodies against HSV-1, suggesting past infection. Negative results mean no detectable antibodies, which could mean you’ve never been exposed or the test was taken too early after exposure. Always discuss results with your provider for personalized interpretation.

Common Reasons for Testing

This test is often used to diagnose herpes simplex virus type 1 infections in people with recurrent cold sores, to evaluate immune response after vaccination, or to monitor chronic infections in individuals with compromised immune systems.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to HSV-1

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 3 to 7 business days, depending on your lab’s processing schedule. Your healthcare provider will contact you once the results are ready.
Can I have my blood drawn if I have a cold or flu?
It’s generally safe to have blood drawn if you have a mild cold or flu, as the procedure itself is not contagious. However, if you have a severe infection or fever, let your healthcare provider know before the test to avoid unnecessary risks.
Does this test show if I currently have an active HSV-1 infection?
No, this test measures antibodies, which indicate past exposure rather than active infection. If you suspect you have an active HSV-1 infection, your provider may recommend additional testing or monitoring.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy