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Herpes Simplex Virus Type 1 (HSV-1) Nucleic Acid Detection by Molecular Probe Assay (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of genetic material from the herpes simplex virus type 1 (HSV-1) in your blood or plasma. It helps determine if you have an active infection or have been exposed recently.

Quick summary

["This test helps diagnose active herpes infections or recent exposure to HSV-1."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34655-1
Short code
HSV1+2 DNA # CSF NAA+probe
Synonyms
HSV1+2 DNA # CSF NAA+probe
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like sore throat, fever, or unusual rashes that could be caused by HSV-1. It may also be used in certain research or screening contexts where detecting viral DNA is important, such as in immunocompromised individuals or during outbreaks.

What to Expect Before the Test

No special preparation is needed for this test. You may have a blood sample drawn from a vein in your arm, similar to other blood tests. If you’re concerned about discomfort, let your healthcare provider know.

What the Test Results Mean

A positive result means HSV-1 genetic material was found in your sample. This could indicate an active infection or recent exposure. A negative result means no detectable genetic material was found at the time of testing. Results should always be interpreted by a healthcare professional in the context of your symptoms and medical history.

Possible Side Effects

Most people experience only mild discomfort or bruising at the site where the blood was drawn. Rarely, there may be slight swelling or redness. If you develop signs of infection (like fever or increased pain) at the site, contact your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HSV-1 DNA Test

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 1 to 3 business days, depending on lab processing times and your healthcare provider’s workflow. Your provider will contact you once results are ready.
Can this test detect past infections?
This test specifically detects active HSV-1 infection by looking for viral DNA. It may not detect past infections without symptoms or latent infections, which are common in many people. Antibody tests (like serology) can sometimes provide additional context for past exposure.
Is there any risk of false-positive or false-negative results?
While molecular assays like this are highly sensitive and specific, no test is perfect. False negatives may occur if the sample was taken too early in the infection or if the viral load is very low. False positives are rare but can happen due to laboratory errors or cross-contamination. Always discuss results with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy